Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

M Schlitzer; A Winter-Vann; P J Casey

doi:10.1016/s0960-894x(00)00685-5

Non-peptidic, non-prenylic inhibitors of the prenyl protein-specific protease Rce1

Bioorg Med Chem Lett. 2001 Feb 12;11(3):425-7. doi: 10.1016/s0960-894x(00)00685-5.

Authors

M Schlitzer¹, A Winter-Vann, P J Casey

Affiliation

¹ Institut für Pharmazeutische Chemie, Philipps-Universität Marburg, Germany. schlitze@mailer.uni-marburg.de

PMID: 11212127
DOI: 10.1016/s0960-894x(00)00685-5

Abstract

Several compounds designed as bisubstrate analogues of protein farnesyltransferase inhibited the prenyl protein-specific protease Rce1, qualifying them as lead structures for a novel class of non-peptidic, non-prenylic inhibitors of this protease.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Alkyl and Aryl Transferases / antagonists & inhibitors
Combinatorial Chemistry Techniques
Endopeptidases / drug effects*
Farnesyltranstransferase
Humans
Inhibitory Concentration 50
Molecular Mimicry
Peptides / chemical synthesis
Peptides / pharmacology
Protease Inhibitors / chemical synthesis*
Protease Inhibitors / pharmacology
Structure-Activity Relationship

Substances

Peptides
Protease Inhibitors
Alkyl and Aryl Transferases
Farnesyltranstransferase
Endopeptidases
RCE1 protein, human

Grants and funding

GM46372/GM/NIGMS NIH HHS/United States